An anxiolytic (also anti-panic or antianxiety agent) is a medication, or other intervention, that inhibits anxiety. This effect is in contrast to anxiogenic agents, which increase anxiety. Together these categories of psychoactive compounds or interventions may be referred to as anisotropic compounds or agents. Some recreational drugs such as alcohol induce anxiolysis initially; however, studies show that many of these drugs are anxiogenic. Anxiolytic medications have been used for the treatment of anxiety disorder and its related psychological and physical symptoms. Light therapy and other interventions have also been found to have an anxiolytic effect. Beta-receptor blockers such as propranolol and oxprenolol, although not anxiolytics, can be used to combat the somatic symptoms of anxiety such as tachycardia and palpitations. Anxiolytics are also known as minor tranquilizers. The term is less common in modern texts and was originally derived from a dichotomy with major tranquilizers, also known as neuroleptics or antipsychotics. There are concerns that some GABAergics, such as benzodiazepines and barbiturates, may have an anxiogenic effect if used over long periods of time.
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Panic Room is a 2002 American thriller film directed by David Fincher. The film stars Jodie Foster and Kristen Stewart as a mother and daughter whose new home is invaded by burglars, played by Forest Whitaker, Jared Leto, and Dwight Yoakam. The script was written by David Koepp.
Koepp’s screenplay was inspired by news coverage in 2000 about panic rooms. The film was Fincher’s fifth feature film, following Fight Club (1999). Fincher and Koepp brought together a crew of people with whom each had worked before. The house and its panic room were built on a Raleigh Studios lot. Nicole Kidman was originally cast as the mother, but she left after aggravating a previous injury. Her departure threatened the completion of the film, but Foster quickly replaced Kidman. The filmmakers used computer-generated imagery to create the illusion of the film camera moving through the house’s rooms. Foster became pregnant during the shooting schedule, so filming was suspended until after she gave birth. The film’s production cost $48 million.
The film was commercially released in the United States and Canada on March 29, 2002. The film grossed $30 million on its opening weekend. In the United States and Canada, it grossed $96.4 million. In other territories, it grossed $100 million for a worldwide total of $196.4 million. Critics generally praised the film. Panic Room has been assessed for its portrayal of childhood and feminism, the elements of video surveillance and diabetes, and its thematic approach to mortality.
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Medically unexplained physical symptoms (MUPS or MUS) are symptoms for which a treating physician or other healthcare providers have found no medical cause, or whose cause remains contested. In its strictest sense, the term simply means that the cause for the symptoms is unknown or disputed—there is no scientific consensus. Not all medically unexplained symptoms are influenced by identifiable psychological factors. However, in practice, most physicians and authors who use the term consider that the symptoms most likely arise from psychological causes. Typically, the possibility that MUPS are caused by prescription drugs or other drugs is ignored. It is estimated that between 15% and 30% of all primary care consultations are for medically unexplained symptoms. A large Canadian community survey revealed that the most common medically unexplained symptoms are musculoskeletal pain, ear, nose, and throat symptoms, abdominal pain and gastrointestinal symptoms, fatigue, and dizziness. The term MUPS can also be used to refer to syndromes whose etiology remains contested, including chronic fatigue syndrome, fibromyalgia, multiple chemical sensitivity, and Gulf War illness. The term medically unexplained symptoms are in some cases treated as synonymous to older terms such as psychosomatic symptoms, conversion disorders, somatic symptoms, somatisations or somatoform disorders; as well as contemporary terms such as functional disorders, bodily distress, and persistent physical symptoms. The plethora of terms reflects imprecision and uncertainty in their definition, controversy, and care taken to avoid stigmatizing sufferers. Risk factors for medically unexplained symptoms are complex and include both psychological and organic features, and such symptoms are often accompanied by other somatic symptoms attributable to organic disease. As such it is recognized that the boundary defining symptoms as medically unexplained is increasingly becoming blurred. Women are significantly more likely than men to be diagnosed with Medically Unexplained Symptoms. Childhood adversity and/or abuse, and the death or serious illness of a close family member are significant risk factors. Many patients presenting with medically unexplained symptoms also meet the diagnostic criteria for anxiety and/or depression. The likelihood of meeting such criteria increases with the number of unexplained symptoms reported. However, anxiety and depression are also very common in individuals with medically explained illnesses, and again, the likelihood of a person receiving one of these diagnoses increases with the number of symptoms reported. Consequently, on the current evidence, we cannot infer that anxiety or depression are causes of medically unexplained physical symptoms.
Physical symptoms have been associated with adverse psychosocial and functional outcome across different cultures, irrespective of etiology (either explained or unexplained).
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Cooking with Dog is a Japanese cooking show web series. It premiered on YouTube on September 9, 2007. The show features a Japanese woman known only as “Chef” who prepares the featured dish of the episode while her toy poodle Francis (via voiceover) narrates the process. While Chef speaks in Japanese, Francis narrates the episodes in English, a decision designed to expand the show’s audience. Though initially focusing on Japanese cuisine, the show later expanded to include cuisine from other regions. New episodes were uploaded each Friday, before switching to a different release structure in early 2017. Despite the show’s popularity and public appearances by Chef, the identities of both Chef and the show’s producer are intentionally undisclosed out of privacy concerns.
Over time, the show has increased in popularity, going from a low budget, low production value channel to gaining a cult following and having over 1.4 million channel subscribers. Reviews have attributed the show’s popularity to its simplicity, granular step-by-step approach to cooking, and Francis and Chef’s pleasant, anxiety-free approach. The show is among YouTube’s 10 most subscribed cooking and food channels and has garnered positive attention, public appearances, and awards.
In 2015, the show’s popularity resulted in a spinoff web series called Go! Francis!, where a stuffed toy version of Francis travels throughout Japan discussing aspects of Japanese food culture, visiting places of culinary interest, and interviewing professionals in the food industry. The web series is also hosted on the same YouTube channel as Cooking with Dog. Francis died in late 2016, prompting an eventual announcement that the show would no longer continue to produce regular content, but would instead release occasional new episodes.
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The Himalaya Drug Company is an Indian company established by M Manal in 1930 and based in Bangalore, India. It produces health care products under the name Himalaya Herbal Healthcare whose products include ayurvedic ingredients. It is spread across locations in India, the United States, the Middle East, Asia, Europe, and Oceania., while its products are sold in 92 countries across the world. The company has more than 290 researchers that utilize ayurvedic herbs and minerals. A Hepatic drug, named Liv.52, is its flagship product, first introduced in 1955. Liv.52 to date has now over 215 clinical trials backing it. Himalaya Global Holdings Ltd. (HGH), is the parent of The Himalaya Drug Company worldwide. It is also the global headquarters of all Himalaya subsidiaries.
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A Cure for Wellness is a 2016 psychological horror film directed by Gore Verbinski, written by Justin Haythe, and starring Dane DeHaan, Jason Isaacs, and Mia Goth. Its plot follows a young executive who is sent to retrieve a colleague from a mysterious rehabilitation center in the Swiss Alps.
An international co-production based in the United States, Germany, and Luxembourg, the film was shot on location at various German locations, including Hohenzollern Castle in Baden-Württemberg. Its screenplay, written by Haythe, is based on a story co-written by Haythe and Verbinski, who were both inspired by Thomas Mann’s 1924 novel The Magic Mountain.
The film was released on February 17, 2017, by 20th Century Fox. The film received mixed reviews and grossed $26 million against its $40 million production budget.
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For the rock band, see Panic! at the Disco.Panic! (known as SWITCH (スイッチ, Suitchi) in Japan) is a puzzle point and click video game developed by Sega and Office I and published by Sega in Japan and Data East USA in North America for the Sega CD, in collaboration with the Theatrical Group WAHAHA Hompo. It was released on April 23, 1993, in Japan, localized to North America in 1994, and later released for the PlayStation 2 in Japan on August 8, 2002. The game involves pressing numerous buttons in order to transverse a young boy, called Slap, or his dog, called Stick, through a complex labyrinth. It is one of the few Sega CD games that support the Sega Mega Mouse.
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Social anxiety disorder (SAD), also known as social phobia, is an anxiety disorder characterized by a significant amount of fear in one or more social situations, causing considerable distress and impaired ability to function in at least some parts of daily life. These fears can be triggered by perceived or actual scrutiny from others. Individuals with social anxiety disorder fear negative evaluation from other people.
Physical symptoms often include excessive blushing, excess sweating, trembling, palpitations, and nausea. Stammering may be present, along with rapid speech. Panic attacks can also occur under intense fear and discomfort. Some sufferers may use alcohol or other drugs to reduce fears and inhibitions at social events. It is common for sufferers of social phobia to self-medicate in this fashion, especially if they are undiagnosed, untreated, or both; this can lead to alcoholism, eating disorders or other kinds of substance abuse. SAD is sometimes referred to as an illness of lost opportunities where “individuals make major life choices to accommodate their illness”. According to ICD-10 guidelines, the main diagnostic criteria of social phobia are fear of being the focus of attention or fear of behaving in a way that will be embarrassing or humiliating avoidance and anxiety symptoms. Standardized rating scales can be used to screen for social anxiety disorder and measure the severity of anxiety.
The first line of treatment for social anxiety disorder is cognitive-behavioral therapy (CBT). Medications such as SSRIs are effective for social phobia, especially paroxetine. CBT is effective in treating this disorder, whether delivered individually or in a group setting. The cognitive and behavioral components seek to change thought patterns and physical reactions to anxiety-inducing situations. The attention given to social anxiety disorder has significantly increased since 1999 with the approval and marketing of drugs for its treatment. Prescribed medications include several classes of antidepressants: selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs). Other commonly used medications include beta-blockers and benzodiazepines.
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