A cold chill (also known as chills, the chills or simply thrills) is described by David Huron as, “a pleasant tingling feeling, associated with the flexing of hair follicles resulting in goose bumps (technically called piloerection), accompanied by a cold sensation, and sometimes producing a shudder or shiver.” Dimpled skin is often visible due to cold chills especially on the back of the neck or upper spine. Unlike shivering, however, it is not caused by temperature, menopause, or anxiety but rather is an emotionally triggered response when one is deeply affected by things such as music, speech, or recollection. It is similar to autonomous sensory meridian response; both sensations consist of a pleasant tingling feeling that affects the skin on the back of the neck and spine.

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Horizon is a current and long-running BBC popular science and philosophy documentary programme. Series one was broadcast in 1964 and as of October 2016 is in its 52nd series. Over 1200 episodes have been broadcast (including specials) with an average of 24 episodes per series during the 52-year run. 1964–1969 – 135 episodes 1970–1979 – 299 episodes 1980–1989 – 234 episodes 1990–1999 – 220 episodes 2000–2009 – 193 episodes Since 2010 – 126 episodes

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Separation anxiety disorder (SAD), is an anxiety disorder in which an individual experiences excessive anxiety regarding separation from home or from people to whom the individual has a strong emotional attachment (e.g., a parent, caregiver, significant other or siblings). It is most common in infants and small children, typically between the ages of 6–7 months to 3 years, although it may pathologically manifest itself in older children, adolescents and adults. Separation anxiety is a natural part of the developmental process. Unlike SAD (indicated by excessive anxiety), normal separation anxiety indicates healthy advancements in a child’s cognitive maturation and should not be considered a developing behavioral problem.According to the American Psychiatric Association, separation anxiety disorder is an excessive display of fear and distress when faced with situations of separation from the home or from a specific attachment figure. The anxiety that is expressed is categorized as being atypical of the expected developmental level and age. The severity of the symptoms ranges from anticipatory uneasiness to full-blown anxiety about separation.SAD may cause significant negative effects within areas of social and emotional functioning, family life, and physical health of the disordered individual. The duration of this problem must persist for at least four weeks and must present itself before a child is 18 years of age to be diagnosed as SAD in children, but can now be diagnosed in adults with a duration typically lasting 6 months in adults as specified by the DSM-5.

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Vaginal lubrication is a naturally produced fluid that lubricates a woman’s vagina. Vaginal lubrication is always present, but production increases significantly near ovulation and during sexual arousal in anticipation of sexual intercourse. Vaginal dryness is the condition in which this lubrication is insufficient, and sometimes artificial lubricants are used to augment it. Without sufficient lubrication, sexual intercourse can be painful. The vaginal lining has no glands, and therefore the vagina must rely on other methods of lubrication. Plasma from vaginal walls due to vascular engorgement is considered to be the chief lubrication source, and the Bartholin’s glands, located slightly below and to the left and right of the introitus (vaginal opening), also secrete mucus to augment vaginal-wall secretions. Near ovulation, cervical mucus provides additional lubrication.

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Andhra Pradesh State Road Transport Corporation (or APSRTC) is the state-owned road transport corporation in the Indian state of Andhra Pradesh. Its headquarters are located at NTR Administrative Block of RTC House in Pandit Nehru bus station of Vijayawada. Many other Indian metro towns in Telangana, Tamil Nadu, Karnataka, Odisha, Yanam and Chhattisgarh are also linked with the services of APSRTC.

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Premature ovarian failure (POF) is the loss of function of the ovaries before age 40. A commonly cited triad for the diagnosis is amenorrhea, hypergonadotropism, and hypoestrogenism. If it has a genetic cause, it may be called gonadal dysgenesis.The term “primary ovarian insufficiency” was first used in 1942 by Fuller Albright who first described the condition. About 5 to 10% of women with primary ovarian insufficiency conceive subsequent to the diagnosis without medical intervention.

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General anaesthesia or general anesthesia (see spelling differences) is a medically induced coma with loss of protective reflexes, resulting from the administration of one or more general anaesthetic agents. It is carried out to allow medical procedures that would otherwise be intolerably painful for the patient; or where the nature of the procedure itself precludes the patient being awake. A variety of drugs may be administered, with the overall aim of ensuring unconsciousness, amnesia, analgesia, loss of reflexes of the autonomic nervous system, and in some cases paralysis of skeletal muscles. The optimal combination of drugs for any given patient and procedure is typically selected by an anaesthetist, or another provider such as an operating department practitioner, anaesthetist practitioner, physician assistant or nurse anaesthetist (depending on local practice), in consultation with the patient and the surgeon, dentist, or other practitioner performing the operative procedure.

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Generalized anxiety disorder (GAD) is an anxiety disorder characterized by excessive, uncontrollable and often irrational worry, that is, apprehensive expectation about events or activities. This excessive worry often interferes with daily functioning, as individuals with GAD typically anticipate disaster, and are overly concerned about everyday matters such as health issues, money, death, family problems, friendship problems, interpersonal relationship problems, or work difficulties. Individuals may exhibit a variety of physical symptoms, including feeling tired, fidgeting, headaches, numbness in hands and feet, muscle tension, difficulty swallowing, upset stomach, vomiting, diarrhea, breathing difficulty, difficulty concentrating, trembling, irritability, sweating, restlessness, sleeping difficulties, hot flashes, rashes, and inability to fully control the anxiety. These symptoms must be consistent and ongoing, persisting at least six months, for a formal diagnosis of GAD.Standardized rating scales such as GAD-7 can be used to assess severity of GAD symptoms. GAD is the most common cause of disability in the workplace in the United States.In a given year, approximately two percent of American adults and European adults experience GAD. Globally about 4% are affected at some point in their life. GAD is seen in women twice as much as men. GAD is also common in individuals with a history of substance abuse and a family history of the disorder. Once GAD develops, it may become chronic, but can be managed or eliminated with proper treatment.

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Night sweats, also known as nocturnal hyperhidrosis, is the occurrence of excessive sweating during sleep. The person may or may not also perspire excessively while awake. One of the most common causes of night sweats in women over 40 is the hormonal changes related to menopause and perimenopause. This is a very common occurrence during the menopausal transition years. While night sweats might be relatively harmless, it can also be a sign of a serious underlying disease. It is important to distinguish night sweats due to medical causes from those that occur simply because the sleep environment is too warm, either because the bedroom is unusually hot or because there are too many covers on the bed. Night sweats caused by a medical condition or infection can be described as “severe hot flashes occurring at night that can drench sleepwear and sheets, which are not related to the environment”. Some of the underlying medical conditions and infections that cause these severe night sweats can be life-threatening and should promptly be investigated by a medical practitioner.

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